Plague Pipeline

EV76 further attenuated by deleting plasminogen activator

A Chinese derivative of the old EV76 live vaccine. The plasminogen activator gene pla is deleted to cut residual virulence. It was tested by putting bacteria into the trachea, a lung model, in a 2020 report. Preclinical. State institutes, no listing.

Stage chart

Preclinical

Phase 1

Phase 2

Phase 3

Licensed

Preclinical · intratracheal. Phase 3 is empty here, as it is for every programme in the set.

Years on the record

A mark at 2020. Labelled “2020” on the briefing. Not a forecast.

Analyst card

Challenge: Intratracheal challenge, a lung model, in a 2020 report.
F1-negative strains: Not reported. pla is deleted. That is attenuation, not an antigen.
Adjuvant: None. Live EV76 derivative.
Route: Not stated.
Stability: Formulation and cold-chain requirement are not stated.
Time to protection: Not reported. No time-to-protection figure is in the briefing.
Other threats: Plague only.
Survival figure: No survival percentage in the briefing.
Animal Rule: Preclinical. Not a US file.

Pipeline record

Parent: The old EV76 live vaccine.
Change: The plasminogen activator gene pla is deleted, to cut residual virulence.
Model: Bacteria placed in the trachea, a lung model. Reported in 2020. Preclinical.
Owner: Chinese state institutes. No listing.

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Platform: Live attenuated
A weakened whole bacterium, not a purified protein. EV76 is the long-standing example; newer constructs delete extra virulence genes and are still in animals.
Who is paying: China — state institutes
Country: China
What was tested: Intratracheal
Stage: Preclinical · intratracheal
Date: 2020
Antigens named: Whole organism