Who is building them · What platform · Who is paying

Overview

Twenty-one named plague-vaccine programmes. Six are already in people. One new-generation shot has a marketing authorisation, in Russia. None is approved in the United States or the European Union.

Each programme

One bar per vaccine, coloured by platform. Drag the year to dim programmes that were not yet on the record.

01 EV76-NIIEG2002 to 2026. Licensed · Phase 4.02 PMMM — microencapsulated rF1 + rV2024. Marketing authorisation.03 rF1V + CpG 10182021 to 2026. Phase 2 · enrolled Q3 2025.04 Native F1 + rV in alum2014 to 2026. Phase 2a → Phase 2b.05 ChAdOx1 Plague (F1 + V)2021. Phase 1 · n=40.06 rF1V + flagellin adjuvant2009 to 2026. Phase 1.07 F1 mRNA-LNP — single dose2023. Preclinical · bubonic.08 Bivalent F1 + LcrV mRNA-LNP2025. Preclinical · pneumonic.09 Self-amplifying RNA-LNP, F1 + V2023. Preclinical · bubonic.10 Ad5-YFV — YscF / F1 / LcrV2016 to 2021. Preclinical · primates.11 CO92 ΔlppΔmsbBΔail / Δpla (LMA, LMP)2015 to 2016. Preclinical · pneumonic.12 CO92 Δpgm / ΔpPst · ΔyscN2021. Preclinical · aerosol.13 EV76-B-SHUΔpla2020. Preclinical · intratracheal.14 VTnF1 — oral, single dose2015 to 2020. Preclinical · both forms.15 Outer-membrane vesicles + modified LPS2022. Preclinical · pneumonic.16 Salmonella Typhimurium — F1 / Psn / V2004 to 2016. Preclinical.17 F. tularensis LVS — F1 / LcrV + anthrax PA2018. Preclinical · respiratory.18 Bacteriophage T4 nanoparticle — F1-V + PA2018. Preclinical · pneumonic.19 Polyanhydride nanovaccine — rF1V2019. Preclinical · pneumonic.20 DNA fusion vaccine — anthrax / plague2012. Preclinical · aerosol.21 Peptidoglycan-free bacterial ghosts2022. Preclinical.

Listed company

One of the twenty-one programmes has a public owner. The rest are state institutes, universities, or defense laboratories.

03 rF1V + CpG 1018

Sanofi Nasdaq:SNY

$40.20+0.64 (+1.62%)

Last close on file · 7 Oct 2026, 16:00 EDT

Sanofi bought Dynavax in February 2026. Dynavax supplied CpG 1018 and this rF1V candidate, then left the Nasdaq. Its last print was $15.50 on 9 February 2026. The US Department of Defense still funds the trial.

Where the work sits

Amber is already in humans. Stone is still in animals. Click a bar to open that country.

Platform mix

Click a bar to filter the pipeline.

Already in humans

Open in pipeline

Stages, dates, and funders follow one briefing — not a live regulator feed. EV76 is counted in both Russia and China on the country chart. This is not medical advice.