Plague Pipeline

Gold-coated constructs delivered by gene gun

USAMRIID, 2012. DNA encoding a fused anthrax and plague antigen, coated onto gold and driven into skin with a gene gun. Animals were challenged by aerosol. The programme stayed preclinical. Fort Detrick is a defense laboratory, not a quoted company.

Stage chart

Preclinical

Phase 1

Phase 2

Phase 3

Licensed

Preclinical · aerosol. Phase 3 is empty here, as it is for every programme in the set.

Years on the record

A mark at 2012. Labelled “2012” on the briefing. Not a forecast.

Analyst card

Challenge: Aerosol challenge in animals, 2012.
F1-negative strains: Not reported.
Adjuvant: None named.
Route: Gene gun. DNA coated on gold, shot into skin.
Stability: Formulation and cold-chain requirement are not stated.
Time to protection: Not reported. No time-to-protection figure is in the briefing.
Other threats: A fused anthrax and plague antigen.
Survival figure: No survival percentage in the briefing. The programme stayed preclinical.
Animal Rule: Preclinical USAMRIID work. Not an Animal Rule approval.

Pipeline record

Lab: USAMRIID, 2012.
Format: DNA for a fused anthrax and plague antigen, coated on gold and shot into skin with a gene gun.
Model: Aerosol challenge in animals. The programme stayed preclinical.
Owner: Fort Detrick, a defense laboratory. Not a quoted company.

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Platform: DNA
Antigen genes on a DNA construct. The programme in this set used gold-coated DNA shot in with a gene gun, and stayed preclinical.
Who is paying: US — USAMRIID, Fort Detrick
Country: United States
What was tested: Aerosol
Stage: Preclinical · aerosol
Date: 2012
Antigens named: With anthrax